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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2016 Jul;25(4):308–313. doi: 10.1097/MNH.0000000000000239

Figure 3.

Figure 3

CaSR signaling cascade in the kidney. A feedback control loop of CaSR regulation in the TALH includes the following key components: microRNAs (miR-9 and miR-374) and claudin-14. Claudin-14 negatively regulates claudin-16 and -19 permeability via direct interaction. MicroRNAs regulate claudin-14 mRNA stability and translational efficacy. The gene transcription of microRNAs themselves is regulated by the transcriptional factor – NFAT and via deacetylation of nearby histone molecules. NFAT: nuclear factor of activated T cells; CsA: cyclosporine A; SAHA: suberanilohydroxamic acid.