Table 2.
Biodistribution of AAV genomes determined by qPCR (number of vector genomes per µg DNA
| Tissue | Dog 2 | Dog 3 |
|---|---|---|
| Aqueous humor OD | 54 275 | 2505 |
| Aqueous humor OS | 6 220 225 | 1525 |
| Optic nerve OD | 90 | 145 |
| Optic nerve OS | 710 | 10 |
| Optic chiasm | 31 | 52 |
| Cerebrum | 0 | 0 |
| Cerebellum | 0 | 14 |
| Parotid gland | 0 | 0 |
| Submandibular lymph node | 0 | 0 |
| Lung | 0 | 0 |
| Heart | 10 | 0 |
| Liver | 53 | 3 |
| Pancreas | 0 | 0 |
| Spleen | 611 | 581 |
| Kidney | 6 | 19 |
Abbreviations: AAV, adeno-associated virus; OD, right eye; OS, left eye; qPCR, quantitative PCR.
The bold values in the table represent positive results >2.