Table 3.
Conditional logistic regression analysis of creatine riboside and NANA in all, European- and African-American subjects.
| Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
| Metabolitea | N(%) Cases |
N(%) Controls |
OR (95% CI) | p-valueb | N(%) Cases |
N(%) Controls |
OR (95% CI)c,d | p-valueb |
| All | ||||||||
| Low | ||||||||
| Referentcr | 109 (61) | 262 (75) | 1.00 | 101 (60) | 237 (25) | 1.00 | ||
| Referentnana | 109 (61) | 262 (75) | 1.00 | 101 (60) | 231 (74) | 1.00 | ||
| High | ||||||||
| Creatine Riboside | 69 (39) | 87 (25) | 2.0 (1.3–3.0) | 0.001 | 66 (40) | 77 (25) | 2.0 (1.2–3.4) | 0.01 |
| NANA | 69 (39) | 87 (25) | 2.0 (1.3–3.0) | 0.001 | 66 (40) | 83 (26) | 1.6 (1.0–2.6) | 0.08 |
| European-Americans | ||||||||
| Low | ||||||||
| Referentcr | 51 (69) | 123 (85) | 1.00 | 49 (68) | 116 (87) | 1.00 | ||
| Referentnana | 40 (54) | 109 (76) | 1.00 | 38 (53) | 99 (74) | 1.00 | ||
| High | ||||||||
| Creatine Riboside | 23 (31) | 21 (15) | 2.7 (1.3–5.4) | 0.005 | 23 (32) | 18 (13) | 5.3 (1.6–17.6) | 0.006 |
| NANA | 34 (46) | 35 (24) | 2.8 (1.5–5.2) | 0.001 | 34 (47) | 35 (26) | 3.5 (1.5–8.4) | 0.004 |
| African-Americans | ||||||||
| Low | ||||||||
| Referentcr | 52 (54) | 122 (66) | 1.00 | 48 (53) | 113 (66) | 1.00 | ||
| Referentnana | 64 (67) | 137 (74) | 1.00 | 59 (66) | 124 (73) | 1.00 | ||
| High | ||||||||
| Creatine Riboside | 44 (46) | 63 (34) | 1.6 (1.0–2.7) | 0.06 | 42 (47) | 58 (34) | 1.1 (0.6–2.3) | 0.73 |
| NANA | 32 (33) | 48 (26) | 1.4 (0.8–2.4) | 0.20 | 31 (34) | 47 (27) | 0.9 (0.4–1.8) | 0.69 |
a
Levels dichotomized into high and low based on the 75th percentile of population control abundances (low = referent).
b
Statistically significant; p-value <0.05.
c
Multivariate conditional logistic regression adjusted for age, BMI, income, education level, prior history of COPD, family history of lung cancer, smoking status and pack years. Individually matched controls selected in 2:1 ratio to cases using incidence density sampling matched by age (+/− 2 years), sex, race, CHC recruitment site, menopausal status (women), and date of sample collection (+/− 6 months).
d
OR: odds ratio; CI: confidence interval