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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Cancer Res. 2016 Mar 24;76(11):3145–3155. doi: 10.1158/0008-5472.CAN-15-2511

Figure 6.

Figure 6

Role of MMP-3 on tumor growth and metastasis in vivo. Silencing MMP-3 in A375SM melanoma cells inhibited tumor growth and experimental lung metastases in nude mice, while overexpression of MMP-3 in SB2 cells increased both tumor growth and metastasis. (A) Tumor growth of A375SM cells was significantly reduced after silencing MMP-3; (*P < 0.05). (B) Tumor growth of SB2 cells was significantly increased after overexpressing MMP-3; (*P < 0.05) (C) Six weeks after intravenous injections of A375SM cells, silencing MMP-3 significantly reduced the number of experimental lung metastases; (*P < 0.05). (D) In SB2 cells, overexpressing MMP-3 significantly increased the number of experimental lung metastases; (*P < 0.01).