Table 1.

Proteins that interact with MNB/DYRK1A.

Symbol	Name	Subcellular location	Biological process	Mouse Protein identification	Int.	Reference
Amph	Amphiphysin	Cytoplasm	Synaptic vesicle endocytosis	Q7TQF7	P	Murakami et al., 2006
App, b-amyloid	Amyloid precursor protein, β-amyloid precursor protein	Cytoplasm	Apoptosis, Cell adhesion, Endocytosis	P12023	P, RE	Kimura et al., 2007; Ryoo et al., 2008
Arip4	Androgen Receptor Interacting Protein 4	Nucleus	ATP, DNA and Nucleotide-binding	Q99NG0	Int.	Sitz et al., 2004
Braf	Braf transforming gene	Cytoplasm, Nucleus	ATP, Metal and Nucleotide-binding	P28028	Int.	Kelly and Rahmani, 2005
Casp-9	Cystein aspartyl protease Caspase 9	Cytoplasm, Nucleus	Apoptosis	Q8C3Q9	P	Laguna et al., 2008; Seifert et al., 2008
Ccnd1	Cyclin D1, cyclin family	Nucleus, Cytoplasm	Cell cycle and division, Transcription	P25322	P	Chen et al., 2013; Najas et al., 2015
Ccnl2	Cyclin L2, cyclin family	Nucleus	Transcription regulation	Q9JJA7	P	De Graaf et al., 2004
CreB	cAMP response element-binding protein	Nucleus	Differentiation, Transcription regulation	Q01147	P	Yang et al., 2001
Cry2	Cryptochrome Circadian Clock 2	Cytoplasm, Nucleus	Biological rhythms, Sensory transduction, Transcription regulation	Q9R194	P	Kurabayashi et al., 2010
CTD RnaP II	CTD of the RNA polymerase II	Nucleus	Transcription	P08775	P, DNA binding	Di Vona et al., 2015
Dnm1	Dynamin 1	Cytoplasm	Endocytosis	P39053	P	Chen-Hwang et al., 2002
Endophilin 1	Endophilin 1	Cytoplasm, Membrane	Endocytosis	Q62420	B	Murakami et al., 2009
Fkhr	Forkhead box O1	Cytoplasm, Nucleus	Apoptosis, Autophagy, Differentiation, Transcription regulation	Q9R1E0	P	Woods et al., 2001
Gli1	Glioma-associated oncogene 1	Cytoplasm, Nucleus	Differentiation, Transcription regulation	P47806	P	Mao et al., 2002
Grb2	Growth factor receptor bound protein 2	Cytoplasm, Nucleus	Cell differentiation	Q60631	Int.	Abekhoukh et al., 2013
Gsk3B	Glycogen synthase kinase 3 beta	Nucleus, Cytoplasm, Membrane	Differentiation, Neurogenesis	Q9WV60	P	Skurat and Dietrich, 2004
Grin2a	glutamate receptor, ionotropic, NMDA2A	Cell membrane, Cell junction	Ion transport, Transport	P35436	P	Grau et al., 2014
Hip1	Huntingtin interacting protein 1	Nucleus	Apoptosis, Differentiation, Endocytosis, Transcription regulation	Q8VD75	P	Kang et al., 2005
Kip1	Cyclin-dependent kinase inhibitor 1B	Cytoplasm	Cell cycle	P46414	P	Soppa et al., 2014
Lin52	Protein lin-52 homolog	Nucleus	Cell cycle, transcription	Q8CD94	P	Litovchick et al., 2011
Map1b	Microtubule-associated protein	Cytoplasm	Axon extension, intracellular transport	P14873	P	Scales et al., 2009
Mek1	Dual specificity mitogen-activated protein kinase kinase 1	Cytoplasm, Nucleus	ATP-binding, Nucleotide-binding	P31938	Int.	Kelly and Rahmani, 2005
Nfatc	Nuclear factor of activated T cells	Cytoplasm, Nucleus	Transcription regulation	O88942, Q60591, P97305, Q8K120	P	Arron et al., 2006; Gwack et al., 2006
Notch	Notch Signaling Pathway	Nucleus	Angiogenesis, Differentiation, Transcription	Q01705	P	Fernandez-Martinez et al., 2009
Nrsf / Rest	RE1-silencing transcription factor	Nucleus	Transcription regulation	Q8VIG1	RE	Canzonetta et al., 2008
P53	Transformation related protein 53	Cytoplasm, Nucleus	Transcription Apoptosis, Cell cycle, Necrosis, Transcription	P02340	P	Park et al., 2010
Phyhip	Phytanoyl-COA Hydroxylase-interacting protein	Cytoplasm	Activation of mitophagy	Q8K0S0	B	Bescond and Rahmani, 2005
Park2	Parkin	Cytoplasm, Nucleus	Autophagy, Transcription regulation	Q9WVS6	P	Im and Chung, 2015
Psen1	Presenilin1	Cytoplasm	Apoptosis, Cell adhesion, Notch signaling pathway	P49769	P	Ryu et al., 2010
Ras	GTPase Ras	Cytoplasm	Cell proliferation	Q61411, P32883, P08556	Int.	Kelly and Rahmani, 2005
Rcan1/Dscr1	Regulator of calcineurin 1	Cytoplasm, Nucleus	Calcineurin-NFAT signaling cascade	Q9JHG6	P	Song et al., 2013
Srsf1	Serine/arginine-rich splicing factor 1	Cytoplasm, Nucleus	mRNA processing, splicing and transport	Q6PDM2	P	Shi et al., 2008
Srsf2	Serine/arginine-rich splicing factor 2	Nucleus	RNA splicing	Q62093	P	Qian et al., 2011
Sept4	Septine4	Cytoplasm	GTP-binding, Nucleotide-binding	P28661	P	Sitz et al., 2008
Sf3b1/Sap155	Splicing factor 3b, subunit 1	Nucleus	mRNA processing, mRNA splicing	Q99NB9	P	De Graaf et al., 2006
Sirt1	Sirtuin 1	Cytoplasm, Nucleus	Apoptosis, Differentiation, Myogenesis, Transcription	Q923E4	P	Guo et al., 2010
Snca	a-synuclein	Cytoplasm, Nucleus	Synaptic function	O55042	P	Kim E.J. et al., 2006
Snr1	Integrase interactor 1	Nucleus	Cell cycle, Neurogenesis, Tanscription regulation	Q9Z0H3	P	Kinstrie et al., 2006
Spry2	Sprouty2	Cytoplasm	Developmental protein	Q9QXV8	P	Aranda et al., 2008
Stat3	Signal transducer and activator of transcription 3	Cytoplasm, Nucleus	Acute phase, Transcription, Transcription regulation	P42227	P	Kurabayashi et al., 2015
Synj1	Synaptojanin 1	Cytoplasm	Endocytosis	Q8CHC4	P	Chen C. et al., 2014
Tau	Microtubule-associated protein Tau	Cytoplasm	Brain development	P10637	P	Ryoo et al., 2007
Wasl	Neural Wiskott-Aldrich syndrome protein	Cytoplasm, Nucleus	Cell cycle, Cell division, Mitosis, Transcription	Q91YD9	P	Park et al., 2012
Wdr68	DDB1 and CUL4 associated factor 7	Cytoplasm, Nucleus	Ubl conjugation pathway	P61963	B	Morita et al., 2006; Miyata and Nishida, 2011

P, phosphorylation by Dyrk1A; RE, regulate expression; Int., interaction with Dyrk1A; B, binding with Dyrk1A.