Table 1.
Selected federally funded Alzheimer's biomarker and clinical research trials.
| Study | Source | % AA (%) | Purpose of study |
|---|---|---|---|
| ADNI-1 | Weiner et al., 2013; Alzheimer's Disease Neuroimaging Initiative, 2015 | 4.8 | To develop CSF, blood, and imaging biomarkers as outcome measures using a national cohort of CN, MCI, AD subjects |
| ADNIGO | 3.1 | To examine biomarkers in earlier stage of AD progression by including early MCI | |
| ADNI-2 | 4.3 | To develop CSF, blood, and imaging biomarkers as predictors of cognitive decline and outcome measures | |
| DoD-ADNI | Sibener et al., 2014; Weiner, 2014 | 7.1 | To use imaging and other biomarkers to establish the biological connections between TBI, PTSD and AD in Vietnam War veterans. Enrolment is still ongoing. |
| WHI-Cog | Goveas et al., 2011 | 7.0 | To explore the causal relationship between depressive symptoms in postmenopausal women and MCI/dementia |
| SPRINT-MIND | Ambrosius et al., 2014 | 29.9* | To use cognitive assessments and structural brain imaging to measure the incidence of all-cause dementia in a subset of SPRINT participants |
| Cache County Study on Memory in Aging | Tschanz et al., 2013 | <1** | To examine the role of genetic, psychosocial, and environmental risk factors for AD on its progression and late-life cognitive decline in a 12-year longitudinal study |
| Rush Memory and Aging Project | Bennett et al., 2012 | <12.2** | To use CSF, blood, and postmortem brain neuropathologic evaluation to explore the relationship between age-related cognitive and motor decline and the risk of AD |
| WHICAP | Cosentino et al., 2010 | 31 | To investigate the association between plasma amyloid beta and cognitive change and its implication for risk of AD |
| Brickman et al., 2008 | 34.6 | To use imaging biomarkers to compare brain region volumes among multiethnic cognitively normal elderly | |
| Mayo Clinic Study of Aging | Roberts et al., 2008 | <7.1** | To establish a population-based cohort for studying the prevalence, incidence, and risk factors of MCI and dementia |
%AA, percentage of African-American participants in each study; ADNI, Alzheimer's Disease Neuroimaging Initiative; GO, Grand Opportunities; CN, cognitively normal; MCI, mild cognitive impairment; AD, Alzheimer's disease; DoD, Department of Defense; TBI, Traumatic Brain Injury; PTSD, Post-traumatic Stress Disorder; WHI, Women's Health Initiative; SPRINT, Systolic Blood Pressure Intervention Trial; WHICAP, Washington Heights and Inwood Columbia Aging Project.
The percentage of African-Americans refer to the sample demographics of SPRINT, the parent study of SPRINT-MIND.
The percentage of African-Americans was not mentioned in the studies, and thus was deduced from the percentage of Caucasians; % Caucasian in Cache County Study on Memory and Aging was 99%, Rush Memory and Aging Project was 87.8%, and Mayo Clinic Study of Aging was 92.9%.