Figure 5.

Top: Iterative template Construction. Example of the construction of the template (green frame) of a study of 136 subjects, 9 subjects are displayed. Red frame: the reference subject (OAS2_0017) used for the initialization. Bottom: Influence of the reference subject used to initialize the study-specific template. We built a second study-specific template by initializing it with a different subject (OAS2_0077). We computed $\frac{1}{V}\sum _i|Templat{e}_{OAS2\text{\_}0077}(x_i)-Templat{e}_{OAS2\text{\_}0017}(x_i)|$ over the brain mask at each iteration. Although the initial reference images are dissimilar, we obtain two very similar templates at the end.