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. 2016 Jun 3;10:228. doi: 10.3389/fnins.2016.00228

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Copyright © 2016 Sano, Isobe, Yang, Win-Shwe, Yoshikane, Nakayama, Kawashima, Suzuki, Hashimoto, Nohara, Tohyama and Maekawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of developmental ACE exposure on behavioral flexibility. The comparison of the discrimination error rates (the number of discrimination errors in the first 100 corner visits in the session) in (A) male and (B) female mice. The numbers of animals used are indicated in parentheses. The data are presented as the mean ± SEM. The data for session 38–41 (6th reversal phase) and session 46–53 (8th and 9th reversal phases) in male were omitted due to the technical issues with the IntelliCage apparatus. Thus, the session 42 to 45 is denoted as Rev 6 and the session 54–57 is denoted as Rev 7 on (A).