Table 1.
Clinical and histological characteristics of enrolled patients
| Variables | Value |
|---|---|
| Clinical characteristics (N = 101) | |
| Start of treatment | |
| Age, years | 34 (26–43) |
| Female | 50 (49.5) |
| Tonsillectomya | 50 (49.5) |
| Hypertensionb | 57 (56.4) |
| UPE, g/day | 0.81 (0.58–1.38) |
| U-RBC > 30/hpf | 58 (57.4) |
| eGFR, ml/min/1.73 m2 | 75.1 ± 27.6 |
| Renal dysfunctionc | 33 (32.7) |
| IgA, mg/dl | 323 (253–397) |
| C3, mg/dl | 100 (94–113) |
| IgA/C3 ratio | 3.06 (2.50–3.92) |
| One year after the treatment | |
| UPE, g/day | 0.18 (0.10–0.29) |
| Disappearance of proteinuria | 79 (78.2) |
| Clinical remission | 48 (47.5) |
| Histological characteristics (N = 91)d | |
| HGe | |
| HG1/HG2/HG3/HG4 | 24/49/18/0 (26.4/53.8/19.8/0) |
| Oxford classificationf | |
| M0/M1 | 63/28 (69.2/30.8) |
| E0/E1 | 29/62 (31.9/68.1) |
| S0/S1 | 16/75 (17.6/82.4) |
| T0/T1/T2 | 75/13/3 (82.4/14.3/3.3) |
| Ext absent/Ext present | 6/85 (6.6/93.4) |
Values are presented as the medians (IQR), numbers (%) or mean ± SD
N number of patients, UPE urinary protein excretion, U-RBC urinary sediments of red blood cells, eGFR estimated glomerular filtration rate, M mesangial hypercellularity, E endocapillary hypercellularity, S segmental sclerosis, T tubulointerstitial atrophy/fibrosis, Ext extracapillary hypercellularity, HG histological grade
aTonsillectomy as concurrent treatment
bBlood pressure >130/80 mmHg or receiving any antihypertensive medication
ceGFR <60 ml/min/1.73 m2
dData from patients who underwent renal biopsy within one year before starting treatment
e[8]
f[7]