Table 2.

Therapeutic evaluation for nephrotic syndrome

The therapeutic evaluation is done by the amount of urine protein at 1 and 6 months after the initiation of treatment

Complete remission: urine protein <3.0 g/day

Incomplete remission I: 0.3 g/day ≤ urine protein <1.0 g/day

Incomplete remission II: 1.0 g/day ≤ urine protein <3.5 g/day

Non-response: urine protein ≥3.5 g/day

The diagnosis of nephrotic syndrome and therapeutic evaluation should be done by 24-hour urine collection. If to collect 24-hour urine is impossible, the ratio of urine protein and urine creatinine (g/gCr) at spot urine is available for the diagnosis of nephrotic syndrome and therapeutic evaluation

In principle, the evaluation of complete remission or incomplete remission at 6 months after the initiation of treatment includes the improvement of clinical finings and serum albumin

The evaluation of relapse is the condition that urine protein ≥ 1 g/gCr (1g/gCr) runs or ≥(2+) continues 2–3 times in a row

In Europe and the United States partial remission defines 50% or more of the reduction of urine protein, while the Japanese evaluation does not use this definition