Table 4.

Summary of the potential diagnostic miRs in laryngeal cancer

MiRs	Deregulation	Molecular mechanisms	Ref.
miR-196a	Upregulation	The cancer-specific expression of miR-196a was confirmed in 89 LSCC surgical specimens.	[51]
miR-21	Upregulation	The increased exosomal expressions of miR-21 and HOTAIR were correlated with clinical stages, T classification and lymph node metastasis.	[53]
miR-27a	Upregulation	MiR-27a had a significantly increased expression in LSCC.	[33]
miR-331-3p, 603, 1303, 660-5p, 212-3p	Upregulation	MiR-331-3p, 603, 1303, 660-5p and 212-3p were only detected in LSCC and have never been reported before in plasma of any other human subject.	[25]
miR-657/miR-1287	Upregulation/downregulation	The miR-657/miR-1287 classfier displayed high sensitivity and specificity for differentiating early larynx carcinoma from normal samples.	[55]