Table 6.

Summary of the potential therapeutic target miRs in laryngeal cancer

MiRs	Deregulation	Molecular mechanisms	Ref
miR-1	Downregulation	Suppresses the migration and invasion of LSCC cells by targeting fibronectin1	[63]
miR-129-5p	Downregulation	Inhibits growth and induces apoptosis in LSCC by directly targeting APC and possibly modulating STAT3	[41,64]
miR-155	Upregulation	Enhances proliferation and invasion of human laryngeal squamous cell carcinoma via targeting SOCS1 and STAT3	[37]
miR-206	Downregulation	Promotes proliferation and invasion of laryngeal cancer by regulating VEGF expression	[65]
miR-24	Downregulation	Functions as a tumor suppressor in laryngeal carcinoma partly through downregulation of the S100A8 protein	[66]
miR-30b	Downregulation	Improves the anti-tumor effect of p53-mediated gene therapy	[68]
miR-31-star, miR-1264, miR-3150b-5p and miR-210	Significantly expression altered	Their expressions are significantly changed after paclitaxel treatment	[67]
miR-93	Upregulation	Promotes LSCC cell proliferation, migration and invasion by directly targeting cyclin G2	[69]