Figure 4.

Serpine2 silencing decreases the migration of melanoma SK-MEL-2 cells. A. Migration assay was performed to determine the metastatic potential of cells and representative pictures of the wound distance were taken as indicated. The number of migration cells was quantified. Data were collected from three independent experiments and were average ± S.E. values. **P < 0.01, compared to control cells. (Scale bar represents 50 μm). B. The cell motility was evaluated by Transwell assay and the number of invasion cells was quantified. Scale bars: 50 µm. Data were from three independent experiments and are average ± S.E. values. *P < 0.01, compared to control cells. C. Quantification of MMP-2/9 activity in SK-MEL-2 cells transfected with siSerpine2. Bars are represented as the mean ± S.E. n=3, **P < 0.01 versus siCTL cells.