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Serpine2 regulates GSK3β pathway in melanoma cells. A. Serpine2 down-regulated the expression of pro-metastasis factors in siSerpine2 cells. Gene expression analysis was performed by real-time PCR comparing control SK-MEL-2 cells. Differentially modulated genes were selected and analyzed by hierarchical clustering. B. Western blot shown that the phosphorylation of GSK-3β was inhibited in cells transfected with siSerpine2.
