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. 2016 May 15;8(5):2169–2178.

Figure 2.

Figure 2

Treatment of EPCs with AGEs increased the activity of NADPH oxidase and the protein level of Rac1. A. AGEs increased the optical density, indicating that AGEs increased the activity of NADPH oxidase. Blocking RAGE prevented this effect. Significances of differences are as indicated: n = 5; *P < 0.05 vs control; **P < 0.05 vs AGEs400. B. Rac1 protein levels were assessed by Western blot. AGEs up-regulated Rac1 expression. Blocking RAGE prevented this effect. Significances of differences are as indicated: n = 5; *P < 0.05 vs control; **P < 0.05 vs AGEs400.