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. 2016 May 15;8(5):2222–2233.

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Implantation of rBM-MSC sheet onto the old myocardial infarction (OMI) heart. A. Rabbit BM-MSC sheetswere detached from temperature-responsive culture dishes incubated at < 20°C and the rBM-MSC sheets were thenplaced on Seprafilm^® for delivery to the heart (arrowhead). B. Protocol for sheet implantation onto rabbit OMI. C. Cardiac performance was improved by preconditioned sheet implantation. The change in LVEF (deltaLVEF) and LVFS (deltaLVFS) at 4 weeks post sheet implantation compared to pre-implantation was measured by echocardiograms (n = 5 for each group).