Figure 2.

Sesamin reduced kidney damage and apoptosis induced by ischemic reperfusion. C57/BL6 mice (n = 6) were treated with vehicle or sesamin (100 mg/kg) every 8 h one time for three times within 24 h before surgery. Twenty-four hours after reperfusion, kidneys were collected for histological examination. A. Representative images of damages in the kidney (H&E staining, × 200). B. Statistical analysis of pathological damage scores. C. Representative images of apoptosis in the kidney (TUNEL staining, × 200). D. The activity of caspase-3 in the kidney. Each value is mean ± SD. *P<0.05, **P<0.01 compared with ischemic reperfusion.