Figure 5.

CD39 inhibitor or A2AR antagonist reversed the protective actions of sesamin in IR-operated mice. C57/BL6 mice (n = 6) were treated with sesamin (100 mg/kg) every 8 h one time for three times within 24 h before surgery with or without POM-1 (CD39 inhibitor, 5 mg/kg), SCH-58261 (the A2AAR antagonist, 10 mg/kg), PSB115 (A2BAR antagonist, 10 mg/kg) 30 min before IR. Twenty-four hours after IR, blood and kidney tissues were collected. A. Concentration of serum creatinine. B. Concentration of BUN. C. The tubular damage scores. D. The caspase 3 activity. Data are expressed as the mean ± SD. *P<0.05; **P<0.01.