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. 2016 May 3;114(11):1251–1260. doi: 10.1038/bjc.2016.112

Figure 6.

Figure 6

The speculated concept of the functional difference among LGR5 isoforms.Splice variants of LGR5 expressed at TA cells which proliferate rapidly. LGR5FL expressed specifically at CBCCs. In normal status, unknown substance X affects LGR5 exon 5 and phosphorylation of LRP6 is attenuated. Blocking the binding of substance X by LGR5 exon 5 Ab cause activation of Wnt signalling by LRP6 phosphorylation and the cells get ability of proliferation. As a result, the cells become sensitive to antitumour drug.