Table 3. Adverse events.
| NCI-CTCAE v4.03 | Any grade | Grades 1–2 | Grades 3–4 |
|---|---|---|---|
| Anaemia | 41 (91%) | 31 (69%) | 10 (22%) |
| Neutropenia | 36 (80%) | 18 (40%) | 18 (40%) |
| Thrombocytopenia | 29 (64%) | 24 (53%) | 5 (11%) |
| Febrile neutropenia | 1 (2%) | 0 | 1 (2%) |
| Alopecia | 12 (27%) | 12 (27%) | 0 |
| Anorexia | 42 (93%) | 28 (62%) | 14 (31%) |
| Nausea | 33 (73%) | 30 (67%) | 3 (7%) |
| Vomiting | 17 (38%) | 13 (29%) | 4 (9%) |
| Constipation | 17 (38%) | 17 (38%) | 0 |
| Diarrhoea | 17 (38%) | 16 (36%) | 1 (2%) |
| Abdominal pain | 18 (40%) | 15 (33%) | 3 (7%) |
| Fatigue | 42 (93%) | 27 (60%) | 15 (33%) |
| Hand-foot skin reaction | 19 (42%) | 18 (40%) | 1 (2%) |
| Hyperpigmentation | 18 (40%) | 18 (40%) | 0 |
| Nail change | 10 (22%) | 10 (22%) | 0 |
| Neuropathy–sensory | 14 (31%) | 13 (29%) | 1 (2%) |
| Stomatitis | 26 (58%) | 20 (44%) | 6 (13%) |
| Dysgeusia | 14 (31%) | 14 (31%) | 0 |
| Thrombosis/embolism | 12 (27%) | 0 | 12 (27%) |
| Arterial | 5 (11%) | 0 | 5 (11%) |
| Venous | 7 (16%) | 0 | 7 (16%) |
Abbreviation: NCI-CTCAE v4.03=National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03.