Table 2. Time to Minimum Effective Analgesic Concentration and 90% Steady-state, and Plasma Concentration at Steady-state in Intravenous (IV) Patient-controlled Analgesia with Oxycodone.

Loading dose	2 mg		0.1 mg/kg
Background infusion of 1 mg/h	−	+	−	+
Time to MEAC, h	4	2.7	2.5	2
Time to 90% SS, h	11–16	11–16	9–14	9–14
Cp at SS, ng/ml	79–113	99–142	79–113	99–142

The data show the predicted oxycodone concentration in the plasma over time in hypothetical male and female subjects aged 19, 54, and 89 years after receiving an IV bolus of 2 mg or 0.1 mg/kg followed by demand boluses of 1 mg every 15 minutes with or without background infusion at 1 mg/h. The body weights and heights of all subjects were 60 kg and 165 cm, respectively. MEAC: minimum effective analgesic concentration, SS: steady-state, Cp at SS: plasma concentration at steady-state.