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. 2016 Jun 3;6:27147. doi: 10.1038/srep27147

Figure 2. MK-1064 dose-dependently promotes both NREM and REM sleep during the active phase in rats.

Figure 2

Mean time in active wake, light sleep (LS), SWS, and REM sleep in adult Sprague-Dawley rats monitored for 2 hours post-dose. MK-1064 (5, 10, or 20 mg/kg) or vehicle (20% vitamin E TPGS, orally) was administered in a balanced crossover design such that each animal received drug and vehicle treatments (7 consecutive days). Treatment occurred during the active phase at ZT 17:00, (a) 7 hours prior to lights on (5 mg/kg, n = 5; 10 mg/kg, n = 7; 20 mg/kg, n = 5), or (b) just prior to onset of inactive phase (ZT 23:00; 10 mg/kg, n = 8; 20 mg/kg, n = 7). Mean within-subject change relative to vehicle ± SEM is shown (*, ***p < 0.05 < 0.001, respectively; one sample t-test for repeated measures compared with vehicle).