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. 2016 Jun 3;6:27147. doi: 10.1038/srep27147

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The mean percentage change (±SEM) in (a) active wake, (b) SWS, and (c) REM sleep in response to MK-1064 (at 0.3, 1, 5, 10 and 20 mg/kg) and DORA-12 (at 0.3, 1, 3, 10 and 30 mg/kg) calculated from PSG recordings versus the percentage OX₂R occupancy determined in rats. Occupancy versus plasma exposure curves were determined and the exposure in satellite animals evaluated in parallel with PSG animals was used to determine corresponding OX₂R occupancies at C_max (1 hour) following treatment. Occupancies at which significant % change in active wake, SWS and REM sleep were observed over the 2 hours following treatment relative to vehicle are indicated (*, **, ***p < 0.05, 0.01, 0.001 respectively; one sample t-test for repeated measures).