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. 2016 Jun 3;6:27147. doi: 10.1038/srep27147

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MK-1064 (50, 120 and 250 mg) or placebo were administered 1 hour prior to the normal resting phase in healthy subjects (N = 20), and PSG effects were monitored during the normal resting phase. Effects of MK-1064 versus placebo on time spent in (a) latency to persistent sleep (LPS), latency to REM (LREM), and wake after sleep onset (WASO), and (b) sleep efficiency (SE), total sleep time (TST), NREM, and REM are expressed as the percentage relative to the placebo condition (geometric mean [GM] ratio and 95% confidence limits [CL]; *, **, ***p < 0.05, 0.01, 0.001 respectively; mixed-effects statistical model [see Methods]).