Table 2. |r| values of metabolites accounting for OPLS-DA models of urine samples and statistical analysis for comparison between UUO and control rats.

No	Metabolites	7 Days UUO versus control		14 Days UUO versus control		21 Days UUO versus control		28 Days UUO versus control
		r value	Fold change	r value	Fold change	r value	Fold change	r value	Fold change
1	Isoleucine/leucine	0.77	−0.14**	0.73	−0.17*	0.32	+0.08	0.23	−0.08
2	Lactate	0.20	−0.08	0.25	−0.04	0.57	+0.39*	0.62	+0.65*
3	Acetate	0.11	+0.25	0.34	−0.35	0.53	+0.77*	0.20	−0.31
4	Acetamide	0.33	+0.00	0.30	+0.04	0.35	−0.06	0.48	+0.01
5	N-Acetylglycine	0.79	−0.24**	0.76	−0.25**	0.74	−0.18**	0.53	−0.15*
6	Succinate	0.33	−0.20	0.01	+0.02	0.05	+0.25	0.58	+1.42*
7	2-Ketoglutarate	0.02	+0.05	0.49	+0.47*	0.59	+0.40*	0.67	+0.71*
8	Citrate	0.19	+0.12	0.40	+0.24	0.21	+0.27	0.69	+1.28**
9	Methylamine	0.05	−0.05	0.43	+0.20	0.16	+0.09	0.42	+0.08
10	Dimethylamine	0.08	−0.01	0.29	+0.04	0.21	+0.15	0.31	+0.01
11	Trimethylamine	0.16	+0.09	0.24	+0.27	0.26	+0.37	0.66	+0.25*
12	Creatinine/Creatine	0.63	−0.10*	0.65	−0.23*	0.47	−0.06	0.73	−0.26*
13	cis-Aconitate	0.31	+0.12	0.23	−0.01	0.06	−0.09	0.28	−0.10
15	Taurine	0.21	−0.15	0.53	−0.23*	0.66	−0.23*	0.64	−0.34**
17	trans-Aconitate	0.19	+0.06	0.34	+0.18	0.06	+0.05	0.10	+0.02
18	Glycine	0.58	−0.23*	0.47	+0.14	0.46	+0.29*	0.63	+0.54*
19	Hippurate	0.51	+0.19	0.39	+0.31	0.66	−0.21*	0.26	−0.04
20	Trigonelline	0.47	+0.28	0.28	+0.42	0.16	+0.00	0.15	+0.01
21	1 − MNA	0.24	−0.33	0.24	−0.27	0.40	−0.30	0.61	−0.48*
22	Allantoin	0.42	−0.08	0.45	−0.10	0.53	+0.04	0.64	−0.18*
23	Urea	0.55	+0.09	0.17	+0.02	0.35	−0.09	0.38	−0.20
24	Indoxyl sulfate	0.56	+0.20*	0.30	+0.29	0.66	+0.15*	0.79	+0.45**
26	Niacinamide	0.36	−0.19	0.53	−0.32	0.69	−0.29*	0.48	−0.22
27	Creatinine	0.25	−0.05	0.60	−0.18*	0.09	−0.07	0.65	−0.25*

Key: 1-MNA, 1-Methylnicotinamide; UUO, unilateral ureteral obstruction.