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. 2016 Jun 3;6:27175. doi: 10.1038/srep27175

Figure 3. Vaccination with rCV02 improves cognitive performance in aged 3 × Tg-AD mice following prophylactic and therapeutic administration.

Figure 3

3 × Tg-AD mice were immunized with rCV02 at 3 months (prophylactic; panels (A–C) or 12 months (therapeutic; panels D–F) of age and subjected to the Morris water maze test at 19 months and 21 months of age, respectively. Animals were tested daily for 7 days. (A,D) The mean escape latency (time) to reach the platform on days 1–7 of the water test during the training trials. (B,E) The mean number of platform location crosses during the probe trial after the last training trial. (C,F) Initial latency (time) to reach the platform location in probe trials after the last training trial. Data represent the mean ± SD for each group (n = 6–8). Statistically significant differences were determined by ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group (3 × Tg-AD).