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. 2016 Jun 3;6:27175. doi: 10.1038/srep27175

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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3 × Tg-AD mice were immunized with rCV02 at 3 months (prophylactic; panel A and C) or 12 months (therapeutic; panels B and D) of age. The brains were collected for evaluation at 19 months and 21 months of age, respectively. Levels of dynamin 1 (A,B) and PSD-95 (C,D) in the soluble fractions of the brain homogenates were detected by Western blot analysis; representative images are shown (lanes 1–3, non-vaccinated control 3 × Tg-AD; lanes, 4–6 rCV01-vaccinated 3 × Tg-AD; lanes 6–9, non-vaccinated control C57/BL6). The graphs show the levels of dynamin 1 (A, B) and PSD-95 (C,D) in control and treated mice. Data represent the mean ± SE for each group. Statistically significant differences were determined by ANOVA. *p < 0.05, **p < 0.01, compared with the control group (3 × Tg-AD).