Skip to main content
. 2016 Jun 3;6:27278. doi: 10.1038/srep27278

Figure 4. Schematic representation highlighting the molecular link between the GCN2 pathway and protein O-GlcNAcylation in nutrients-deprived cells.

Figure 4

Following glucose or essential amino acid shortage, activation of the GCN2-eIF2α-ATF4 stress pathway increases GFAT1 production. Consequently, the stimulation of the flux of the HBP contributes to increased protein O-GlcNAcylation.