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. 2016 Jun 3;6:27060. doi: 10.1038/srep27060

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(A) G7-B4 peptide shown in orange stick representation at the surface of Grb7-SH2 domain (grey), with 2Fo-Fc map surrounding G7-B4 shown contoured at 1.2σ. (B) Details of the G7-B4 bound pY binding pocket. G7-B4 and malonic acid (purple sticks) bound to Grb7-SH2. Key amino acids are shown as sticks and hydrogen bonds as dashed lines. (C) G7-B4 oriented to show intramolecular hydrogen bonds. (D) G7-B4NS peptide shown in yellow stick representation at the surface of Grb7-SH2 domain (grey), with 2Fo-Fc map surrounding G7-B4NS shown contoured at 1.2σ. (E) Details of the G7-B4NS pY binding pocket. G7-B4NS and phosphate bound to Grb7-SH2. Key amino acids are shown as sticks and hydrogen bonds as dashed lines. (F) G7-B4NS oriented to show intramolecular hydrogen bonds.