Table 2.
Patient demographics and baseline characteristics (safety population)
| Characteristic | Cohort | All Patients, n=145 | |||||
|---|---|---|---|---|---|---|---|
| A, n=24 | B, n=24 | C, n=24 | D, n=24 | E, n=24 | F, n=25 | ||
| Age, yr, mean (min, max) | 65.9 (44, 83) | 64.3 (32, 79) | 59.2 (25, 78) | 69.8 (48, 81) | 61.8 (32, 78) | 65.2 (41, 77) | 64.4 (25, 83) |
| Men, n (%) | 5 (20.8) | 7 (29.2) | 8 (33.3) | 13 (54.2) | 8 (33.3) | 12 (48.0) | 53 (36.6) |
| Weight, kg, mean (min, max) | 89.9 (53, 139) | 84.5 (55, 122) | 89.5 (48, 138) | 85.1 (48, 125) | 88.3 (56, 140) | 84.7 (48, 122) | 87.0 (48, 140) |
| Race, n (%) | |||||||
| White | 17 (70.8) | 14 (58.3) | 14 (58.3) | 17 (70.8) | 14 (58.3) | 17 (68.0) | 93 (64.1) |
| Black | 7 (29.2) | 7 (29.2) | 9 (37.5) | 5 (20.8) | 7 (29.2) | 7 (28.0) | 42 (29.0) |
| Other | 0 | 3 (12.5) | 1 (4.2) | 2 (8.3) | 3 (12.5) | 1 (4.0) | 10 (6.9) |
| Prevalence, n (%) | |||||||
| Diabetes | 16 (66.7) | 17 (70.8) | 18 (75.0) | 15 (62.5) | 13 (54.2) | 12 (48.0) | 91 (62.8) |
| Hypertension | 10 (41.7) | 13 (54.2) | 14 (58.3) | 11 (45.8) | 15 (62.5) | 16 (64.0) | 79 (54.5) |
| Hb, g/dl, mean (min, max) | 9.6 (7.4,10.6) | 9.7 (8.1, 10.5) | 9.8 (8.8, 10.6) | 9.7 (7.0, 10.6) | 9.9 (8.6, 10.7) | 9.7 (8.6, 10.5) | 9.7 (7.0, 10.7) |
| Ferritin, ng/ml, mean (min, max) | 322 (49, 1711) | 282 (42, 744) | 261 (33, 877) | 283 (38, 1289) | 207 (32, 803) | 306 (37, 689) | 277 (32, 1711) |
| >100, n (%) | 23 (95.8) | 19 (79.2) | 18 (75.0) | 17 (70.8) | 15 (62.5) | 20 (80.0) | 112 (77.2) |
| ≤100, n (%) | 1 (4.2) | 5 (20.8) | 6 (25.0) | 7 (29.2) | 9 (37.5) | 5 (20.0) | 33 (22.8) |
| TSAT, %, mean (min, max) | 24.5 (9, 48) | 19.9 (6, 41) | 21.0 (12, 37) | 24.4 (9, 41) | 20.9 (12, 36) | 21.5 (11, 39) | 22.0 (6, 48) |
| >20, n (%) | 18 (75.0) | 12 (50.0) | 12 (50.0) | 17 (70.8) | 12 (50.0) | 15 (60.0) | 86 (59.3) |
| ≤20, n (%) | 6 (25.0) | 12 (50.0) | 12 (50.0) | 7 (29.2) | 12 (50.0) | 10 (40.0) | 59 (40.7) |
| Iron replete,a n (%) | 18 (75.0) | 11 (45.8) | 11 (45.8) | 14 (58.3) | 9 (37.5) | 13 (52.0) | 76 (52.4) |
min, max, minimum, maximum; Hb, hemoglobin; TSAT, transferrin saturation.
a
Iron replete is defined as TSAT>20% and ferritin >100 ng/ml.