Table 3.
Multivariable linear regression model of the annual decline in eGFR stratified by baseline eGFR
| Baseline Factor | eGFR (CKD-EPI)<60 ml/min per 1.73 m2 (n=78) | eGFR (CKD-EPI) 60–89 ml/min per 1.73 m2 (n=118) | eGFR (CKD-EPI)≥90 ml/min per 1.73 m2 (n=324) | |||
|---|---|---|---|---|---|---|
| β Coefficient (95% CI) | P Value | β Coefficient (95% CI) | P Value | β Coefficient (95% CI) | P Value | |
| Age (per 5 yr) | 0.65 (0.09–1.22) | 0.02 | −0.25 (−0.79 to 0.29) | 0.36 | −0.38 (−0.70 to −0.09) | 0.01 |
| Female | −1.81 (−4.44 to 0.81) | 0.17 | 0.83 (−2.01 to 3.67) | 0.56 | 1.76 (0.51– to 3.01) | 0.01 |
| Baseline CKD-EPI (per 5–ml/min per 1.73 m2 increase) | −0.11 (−0.18 to −0.05) | 0.001 | ||||
| Diabetes | −2.49 (−5.27 to 0.30) | 0.08 | ||||
| Urine ACR (log mg/g) | −0.92 (−1.65 to −0.20) | 0.01 | −1.03 (−1.71 to −0.35) | 0.003 | −0.41 (−0.76 to −0.06) | 0.02 |
| Model R2, % | 23.5 | 8.8 | 7.6 | |||
Final model (n=520). A final multivariable model was identified using covariates selected for entry into a linear regression model. All the variables described in Table 2 were included in the selection. The following covariates were entered into the final model: eGFR<60 ml/min per 1.73 m2: sex, age, urine albumin-to-creatinine ratio (ACR), diabetes; eGFR 60–89 ml/min per 1.73 m2: sex, age, urine ACR; eGFR≥90 ml/min per 1.73 m2: sex, age, urine ACR, baseline eGFR (calculated with CKD-Epidemiology Collaboration formula). CKD-EPI, CKD-Epidemiology Collaboration; 95% CI, 95% confidence interval; ACR, albumin-to-creatinine ratio.