Table 4. Relationship of plasma and CSF sEPCR levels to mortality and neurologic morbidity in children with cerebral malaria.

	Mortality		Neurologic deficit (discharge)		Neurologic deficit (6mo)		Number of seizures after admission		Coma duration (hours)
	OR (95% CI), n	P	OR (95% CI), n	P	OR (95% CI), n	P	β coefficient (95% CI), n	P	β coefficient (95% CI), n	P
Plasma sEPCR (ng/ml)	3.13 (0.36–27.39)a,n = 277	0.30	3.53 (0.76–16.35)b,n = 243	0.11	3.87 (0.12–128)c,n = 233	0.45	0.24 (−0.05–0.54),n = 141	0.11	0.01 (−0.25–0.28),n = 242	0.92
CSF sEPCR (ng/ml)	4.30 (0.17–110)d,n = 76	0.38	0.99 (0.13–7.65)e,n = 70	0.99	0.09 (0.0005–16.14)f,n = 67	0.37	0.20 (−0.13–0.53),n = 38	0.23	0.02 (−0.37–0.40),n = 70	0.92

All models were adjusted for age. Plasma and CSF sEPCR levels were log transformed (log 10).

^aSurvived (n = 247), died (n = 30).

^bDischarged with neurologic deficits (n = 80) vs. without (n = 163).

^cNeurologic deficits at 6-months follow-up (n = 11) vs. not (n = 222).

^dSurvived (n = 70), died (n = 6).

^eDischarged with neurologic deficits (n = 26) vs. without (n = 44).

^fNeurologic deficits at 6-months follow-up (n = 4) vs. not (n = 63).