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Potential role of RBP4 in the vicious cycle of insulin resistance and heart failure. Adipokine RBP4 is regulated by the systemic activation of Ang-II in cardiac hypertrophy/heart failure and by the down-regulation of adipose GLUT4 in insulin resistance (18). RBP4 in turn promotes insulin resistance and cardiac hypertrophy/heart failure through its proinflammatory effects.
