Table 1.
Demographics and Baseline Characteristics by TSH Levels and Presence of Antithyroid Antibodies Among Women with Normal fT4 (0.7–1.85 ng/dL) in the EAGeR Trial
| Characteristics, N (%) | Total | TSH fT4, 0.7–1.85 mIU/L |
Antithyroid Antibodies (Presence of Anti-TPO or Anti-TG Antibodies) |
||||
|---|---|---|---|---|---|---|---|
| <2.5 | ≥2.5 | P Value | Negative | Positive | P Value | ||
| n | 1193 | 884 | 303 | 1018 | 168 | ||
| TSH | 2.1 ± 1.3 | 1.5 ± 0.5 | 3.6 ± 1.5 | <.001 | 1.9 ± 0.9 | 2.9 ± 2.2 | <.001 |
| fT4 | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 | <.001 | 1.1 (0.1) | 1.1 (0.2) | .292 |
| Age, y | 28.7 ± 4.8 | 28.8 ± 4.8 | 28.5 ± 4.7 | .37 | 28.7 ± 4.8 | 28.8 ± 4.7 | .86 |
| BMI, kg/m2 | 26.3 ± 6.5 | 25.9 ± 6.2 | 27.4 ± 7.3 | .001 | 26.1 ± 6.3 | 27.1 ± 7.4 | .08 |
| Race | |||||||
| White | 1126 (94.9) | 835 (94.5) | 291 (96) | .28 | 962 (94.5) | 165 (98.2) | .04 |
| Others | 61 (5.1) | 49 (5.5) | 12 (4) | 56 (5.5) | 3 (1.8) | ||
| Educationa | |||||||
| ≤ High school | 160 (13.5) | 122 (13.8) | 38 (12.5) | .58 | 144 (14.2) | 16 (9.5) | .10 |
| > High school | 1026 (86.5) | 761 (86.2) | 265 (87.5) | 873 (85.8) | 152 (90.5) | ||
| Household income (annual) | |||||||
| ≥ $100 000 | 474 (40) | 348 (39.4) | 126 (41.6) | .77 | 398 (39.1) | 72 (42.9) | .30 |
| $75 000-$99 999 | 144 (12.1) | 110 (12.5) | 34 (11.2) | 124 (12.2) | 21 (12.5) | ||
| $40 000-$74 999 | 175 (14.8) | 136 (15.4) | 39 (12.9) | 155 (15.2) | 21 (12.5) | ||
| $20 000-$39 999 | 302 (25.5) | 221 (25) | 81 (26.7) | 267 (26.3) | 36 (21.4) | ||
| ≤ $19 999 | 91 (7.7) | 68 (7.7) | 23 (7.6) | 73 (7.2) | 18 (10.7) | ||
| Employeda | |||||||
| Yes | 868 (75.7) | 632 (74.4) | 236 (79.7) | .06 | 741 (75.5) | 125 (76.2) | .85 |
| No | 278 (24.3) | 218 (25.6) | 60 (20.3) | 240 (24.5) | 39 (23.8) | ||
| Time from last loss to randomization | |||||||
| ≤ 4 mo | 629 (53.8) | 460 (52.8) | 169 (56.9) | .49 | 544 (54.2) | 87 (53) | .31 |
| 5–8 mo | 214 (18.3) | 163 (18.7) | 51 (17.2) | 179 (17.8) | 35 (21.3) | ||
| 9–12 mo | 96 (8.2) | 70 (8) | 26 (8.8) | 80 (8) | 17 (10.4) | ||
| >12 mo | 230 (19.7) | 179 (20.5) | 51 (17.2) | 201 (20) | 25 (15.2) | ||
| No. of previous pregnancies, not including lossesa | |||||||
| 0 | 506 (42.6) | 363 (41.1) | 143 (47.2) | .12 | 429 (42.1) | 76 (45.2) | .76 |
| 1 | 421 (35.5) | 315 (35.6) | 106 (35) | 364 (35.8) | 57 (33.9) | ||
| 2 | 239 (20.1) | 191 (21.6) | 48 (15.8) | 208 (20.4) | 31 (18.5) | ||
| 3 | 21 (1.8) | 15 (1.7) | 6 (2) | 17 (1.7) | 4 (2.4) | ||
| Number of previous live birthsa | |||||||
| 0 | 550 (46.3) | 392 (44.3) | 158 (52.1) | .01 | 463 (45.5) | 86 (51.2) | .36 |
| 1 | 430 (36.2) | 321 (36.3) | 109 (36) | 374 (36.7) | 57 (33.9) | ||
| 2 | 207 (17.4) | 171 (19.3) | 36 (11.9) | 181 (17.8) | 25 (14.9) | ||
| Smoking in past year | |||||||
| Never | 1033 (87.8) | 764 (87.1) | 269 (89.7) | .46 | 880 (87) | 153 (92.7) | .08 |
| < 6 times/wk | 83 (7.1) | 64 (7.3) | 19 (6.3) | 76 (7.5) | 5 (3) | ||
| Daily | 61 (5.2) | 49 (5.6) | 12 (4) | 55 (5.4) | 7 (4.2) | ||
| Alcohol consumption in past year | |||||||
| Often | 26 (2.2) | 16 (1.8) | 10 (3.3) | .13 | 21 (2.1) | 5 (3) | .22 |
| Sometimes | 369 (31.5) | 285 (32.7) | 84 (28) | 325 (32.3) | 43 (25.9) | ||
| Never | 777 (66.3) | 571 (65.5) | 206 (68.7) | 659 (65.6) | 118 (71.1) | ||
Values are mean ± sd or n (%) as indicated.
a
Data on covariates were missing for education (n = 1), income (n = 1), employment (n = 41), time from last loss to randomization (n = 18), smoking (n = 10), and alcohol (n = 15).