Table 1.

Summary Results of Testing for Longitudinal Stability of the Bins Methylation in 292 Individuals With 2 or More Repeated Measurements, Taken ≥4 Years Apart

Chr	Nini	Nfiltered	Nsign	Max {Rrepeated}	Min {Rrepeated}	Nposit	Corel.1	Corel.2	Corel.3	Max {RMZ}	Max {RDZ}	Nfiltered/Nini	Nsign/Nini	Nposit/Nini
1	997 003	556 000	64 467	0.823	−0.257	58 732	0.501	0.376	0.404	0.889	0.639	0.558	0.065	0.059
2	972 798	563 291	63 797	0.718	−0.256	57 973	0.518	0.365	0.416	0.831	0.690	0.579	0.066	0.060
3	792 090	447 367	48 947	0.766	−0.247	44 425	0.568	0.391	0.431	0.773	0.659	0.565	0.062	0.056
4	764 618	394 755	44 373	0.846	−0.218	40 143	0.582	0.395	0.430	0.934	0.625	0.516	0.058	0.053
5	723 662	394 564	44 526	0.753	−0.236	40 427	0.547	0.393	0.424	0.817	0.719	0.545	0.062	0.056
6	684 461	378 575	42 859	0.774	−0.261	38 963	0.555	0.420	0.447	0.841	0.620	0.553	0.063	0.057
7	636 555	374 256	46 089	0.776	−0.255	42 524	0.513	0.384	0.401	0.821	0.607	0.588	0.072	0.067
8	585 457	336 399	40 097	0.832	−0.255	36 713	0.569	0.390	0.432	0.888	0.623	0.575	0.068	0.063
9	564 854	274 602	34 249	0.764	−0.229	31 573	0.480	0.356	0.380	0.790	0.575	0.486	0.061	0.056
10	542 139	333 790	40 766	0.905	−0.229	37 579	0.505	0.370	0.401	0.934	0.568	0.616	0.075	0.069
11	540 027	312 132	37 634	0.826	−0.253	34 581	0.479	0.347	0.387	0.853	0.572	0.578	0.070	0.064
12	535 408	323 464	37 031	0.780	−0.239	33 766	0.499	0.365	0.390	0.872	0.746	0.604	0.069	0.063
13	460 680	216 253	24 730	0.743	−0.240	22 584	0.534	0.369	0.417	0.787	0.592	0.469	0.054	0.049
14	429 399	214 025	25 936	0.745	−0.230	23 792	0.531	0.399	0.412	0.836	0.599	0.498	0.060	0.055
15	410 126	210 537	26 333	0.802	−0.218	24 261	0.583	0.392	0.430	0.790	0.668	0.513	0.064	0.059
16	361 420	222 438	32 621	0.734	−0.244	30 675	0.457	0.365	0.368	0.789	0.565	0.615	0.090	0.085
17	324 781	229 520	31 730	0.755	−0.241	29 623	0.438	0.372	0.360	0.881	0.592	0.707	0.098	0.091
18	312 309	179 787	20 942	0.830	−0.223	19 148	0.525	0.394	0.426	0.892	0.500	0.576	0.067	0.061
19	236 516	179 218	28 430	0.801	−0.229	27 185	0.406	0.361	0.328	0.837	0.588	0.758	0.120	0.115
20	252 103	166 570	21 391	0.695	−0.220	19 873	0.435	0.329	0.364	0.748	0.534	0.661	0.085	0.079
21	192 520	88 201	12 546	0.738	−0.232	11 730	0.461	0.361	0.382	0.846	0.564	0.458	0.065	0.061
22	205 219	106 187	17 571	0.782	−0.243	16 759	0.413	0.376	0.319	0.797	0.538	0.517	0.086	0.082
ALL	11 524 145	6 501 931	787 065	0.905	−0.261	723 029	0.512	0.377	0.403	0.934	0.746	0.564	0.068	0.063

N_ini, initial number of bins for chromosome; N_filtered, number of bins after filtering: count of 0 per bin <20%; N_sign, number of bins with significant correlation between the sequential (repeated) measurements (R_repeated), with P < .05; N_posit, number of bins with significant and positive correlations between the sequential measurements: P < .05 and R_repeated > 0. Correl.1 and Correl.2 are the correlations between the R_Repeated and R_MZ, and R_Repeated and R_DZ, respectively; Correl.3 is the correlations between R_MZ and R_DZ. All the results are given as an average per chromosome.