Table 2.

Adjusted Mean Changes in Adiponectin Concentrations by Diet Groups at 6 Months and 2 Years

	High-Fat, High-Protein Group	High-Fat, Average-Protein Group	Low-Fat, High-Protein Group	Low-Fat, Average-Protein Group	P Value for Difference	P Value for Interaction
Total population
6 months
Model 1a	0.05 ± 0.06	0.03 ± 0.06	0.05 ± 0.06	0.05 ± 0.06	.98	.05
Model 2b	0.08 ± 0.07	0.04 ± 0.06	0.07 ± 0.06	0.08 ± 0.06	.92	.06
2 y
Model 1a	0.18 ± 0.06c	0.12 ± 0.06c	0.14 ± 0.06c	0.09 ± 0.05	.38	.04
Model 2b	0.23 ± 0.07c	0.17 ± 0.07c	0.17 ± 0.06c	0.15 ± 0.06c	.61	.18
Men
6 months
Model 1a	−0.02 ± 0.08	−0.02 ± 0.07	0.17 ± 0.08c	0.05 ± 0.08	.04	NA
Model 2b	−0.02 ± 0.08	−0.00 ± 0.08	0.19 ± 0.08c	0.09 ± 0.08	.04	NA
2 y
Model 1a	0.13 ± 0.08	0.09 ± 0.08	0.30 ± 0.08c	0.13 ± 0.08	.05	NA
Model 2b	0.18 ± 0.10	0.16 ± 0.09	0.32 ± 0.10c	0.16 ± 0.09	.24	NA
Women
6 months
Model 1a	0.09 ± 0.08	0.07 ± 0.08	−0.00 ± 0.08	0.04 ± 0.08	.57	NA
Model 2b	0.15 ± 0.10	0.10 ± 0.10	0.04 ± 0.09	0.08 ± 0.10	.52	NA
2 y
Model 1a	0.23 ± 0.08c	0.17 ± 0.08c	0.09 ± 0.08	0.08 ± 0.08	.09	NA
Model 2b	0.30 ± 0.10c	0.21 ± 0.09c	0.14 ± 0.09	0.17 ± 0.09	.21	NA

Data are expressed as adjusted least square mean ± SE for changes in adiponectin concentrations. Adiponectin concentrations were log transformed before analysis.

^aAdjusted for age, ethnicity, baseline BMI, and baseline adiponectin concentration. Results in the total population were further adjusted for sex.

^bFurther adjusted for concurrent weight change.

^cSignificant changes compared with baseline with P < .05.