Comparing the OR of OP by categories of serum albumin shows significantly higher odds of OP with hypoalbuminemia at the femoral neck and total femur compared with albumin >4 g/dL in all three models (P ≤ .003) using logistic regression on the weighted samples accounting for hidden variance. At the lumbar spine only, full adjustment has disclosed the association of hypoalbuminemia with OP. Model 1, case-mixed unadjusted model. Model 2, adjusted for age, sex, race, BMI categories, and history of smoking. Model 3, Model 2 plus additionally adjusted for other laboratory values and comorbidities, and components of 24-hour diet recall. Values represent OR ± 95% CI. To convert values of serum albumin to grams per liter, multiply by 10.