Figure 4.
Sleep efficiency as determined by actigraphy in cocaine and control subjects over the course of the week. Activity-based sleep efficiency decreased during cocaine self-administration (n=6; left) compared to Sunday. During the initial 3 weeks at the 3.0mg/kg dose, the reduction was significant from Thursday-Saturday (# P<0.05), whereas during the initial 3 weeks at 4.5mg/kg, activity-based sleep efficiency was significantly reduced from Tuesday-Saturday (* P<0.05). No significant patterns were found in the control group during water self-administration (n=5 right).
