Table 1.
DOC-Score (diagnosing oral cancer with the help of CLE)
| Evaluation criterion | Manifestation | Score |
|---|---|---|
| 1. Tissue architecture | ||
| a) Homogeneity | Completely organized | 0 |
| Organized + unorganized regions | 1 | |
| Completely unorganized | 2 | |
| b) Intercellular gaps | Regular | 0 |
| Mutated | 1 | |
| No longer/non-existent | 2 | |
| 2. Cell morphology | Consistent/regular | 0 |
| Inconsistent/dysplastic (different sizes/shapes/grey levels) | 1 | |
| Completely irregular Dark, small cells Blurry, cloudy image Black spot (cell cluster) |
2 | |
| 3. Fluorescence leakage | Regular | 0 |
| Amplified (bright background) | 1 | |
| 4. Vessels | Regular | 0 |
| Irregular Shape (micro vessels, coiled, elongated etc.) Caliber (increased) Quantity (cumulated) |
1 | |
| x ≥ 5 points = squamous cell carcinoma (SCC) | Max. total: 8 points | |
CLE classification and scoring system of oral squamous cell carcinomas