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. 2016 Jun 3;14:160. doi: 10.1186/s12967-016-0913-x

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Clustered heatmap showing the methylation levels across all samples for the hyper- and hypo-methylated CpG sites. Methylation levels range from dark blue (no methylation) to light yellow (100 % methylated). Dendrograms were computed using Euclidean distance and a complete cluster agglomeration method. Both age groups are clustered correctly and methylation values have a homogeneous intra-group profile. YEAR5 stands for samples of DNA isolated from blood that was collected from individuals when they were 5 years-old. CORD stands for samples of DNA isolated from cord blood that was collected at birth from the same individuals