Table 1.
Gene ontology analysis of hypermethylated GpG sites from birth to 5 years of age (with RR >2 and Q Value <0.001)
| Onthology | Term | RR | Q_value |
|---|---|---|---|
| Biological_process | Digestive tract morphogenesis | 6.3551 | 2.25E−05 |
| Biological_process | Homophilic cell adhesion | 4.6179 | 7.02E−09 |
| Biological_process | Digestive tract development | 3.6972 | 0.0001 |
| Biological_process | Locomotory behavior | 3.6791 | 1.77E−07 |
| Biological_process | Cell–cell adhesion | 3.6197 | 1.63E−07 |
| Biological_process | Digestive system development | 3.3312 | 0.00035 |
| Biological_process | Hindbrain development | 3.1444 | 0.00072 |
| Biological_process | Cell fate commitment | 2.7058 | 0.00011 |
| Biological_process | Behavior | 2.4935 | 2.83E−08 |
| Biological_process | Embryonic organ morphogenesis | 2.4633 | 0.00027 |
| Biological_process | Single-organism behavior | 2.3998 | 3.88E−05 |
| Biological_process | Cell adhesion | 2.3899 | 4.55E−13 |
| Biological_process | Regionalization | 2.381 | 0.00015 |
| Biological_process | Biological adhesion | 2.3795 | 4.55E−13 |
| Biological_process | Brain development | 2.2605 | 4.09E−08 |
| Biological_process | Pattern specification process | 2.2365 | 5.37E−05 |
| Biological_process | Central nervous system development | 2.2029 | 5.18E−10 |
| Biological_process | Muscle structure development | 2.1471 | 0.00017 |
| Biological_process | Embryonic morphogenesis | 2.1396 | 1.59E−05 |
| Biological_process | Embryonic organ development | 2.0979 | 0.00047 |
| Biological_process | Skeletal system development | 2.0909 | 0.00035 |
| Molecular_function | Sequence-specific DNA binding | 2.0117 | 2.71E−06 |
| Cellular_component | Dendrite | 2.3717 | 1.38E−05 |
| Cellular_component | Axon | 2.2741 | 0.00099 |
| Cellular_component | Somatodendritic compartment | 2.1637 | 4.07E−06 |
RR relative risk is a measure of effect size describing the change of proportions between our selected set of genes and a given term
Q value Q value is the result from the adjustment of P values in order to control the false discovery rate (FDR) using the Benjamini-Hochberg method