Table 2.
Gene ontology analysis of hypomethylated GpG sites from birth to 5 years of age (with RR >2 and Q value <0.01)
| Onthology | Term | RR | Q_value |
|---|---|---|---|
| Biological_process | Stress fiber assembly | 23.288 | 0.00494 |
| Biological_process | Positive regulation of T cell mediated immunity | 4.9028 | 0.0066 |
| Biological_process | Regulation of T cell mediated immunity | 4.7907 | 0.00156 |
| Biological_process | Positive regulation of cell killing | 4.4359 | 0.00494 |
| Biological_process | Response to type I interferon | 3.502 | 0.00586 |
| Biological_process | Interferon-gamma-mediated signaling pathway | 3.3269 | 0.00653 |
| Biological_process | Maintenance of protein location in cell | 3.0629 | 0.00181 |
| Biological_process | Cellular response to interferon-gamma | 2.9322 | 0.00494 |
| Biological_process | Maintenance of location in cell | 2.9052 | 0.00191 |
| Biological_process | Response to interferon-gamma | 2.6615 | 0.00496 |
| Biological_process | Actin cytoskeleton organization | 2.0415 | 9.66E−05 |
| Biological_process | Actin filament-based process | 2.0231 | 3.32E−05 |
| Molecular_function | Antigen binding | 3.8842 | 0.00174 |
| Molecular_function | Rho guanyl-nucleotide exchange factor activity | 3.3577 | 0.00237 |
| Molecular_function | Ras guanyl-nucleotide exchange factor activity | 3.0522 | 0.00023 |
| Molecular_function | Guanyl-nucleotide exchange factor activity | 2.2431 | 0.00345 |
| Cellular_component | MHC class I protein complex | 11.685 | 0.00637 |
| Cellular_component | MHC protein complex | 7.2337 | 0.0005 |
| Cellular_component | Integral component of lumenal side of endoplasmic reticulum membrane | 4.8966 | 0.00844 |
| Cellular_component | Lumenal side of membrane | 4.8966 | 0.00844 |
| Cellular_component | Lumenal side of endoplasmic reticulum membrane | 4.8966 | 0.00844 |
| Cellular_component | Main axon | 3.9646 | 0.00124 |
| Cellular_component | Cortical cytoskeleton | 3.0207 | 0.00807 |
| Cellular_component | Axon part | 2.4846 | 0.00206 |
| Cellular_component | Ruffle | 2.1639 | 0.00663 |
RR relative risk is a measure of effect size describing the change of proportions between our selected set of genes and a given term
Q value Q value is the result from the adjustment of P values in order to control the false discovery rate (FDR) using the Benjamini-Hochberg method