Fig. 5.

Testing for convergent CDR3 sequences across patients. Black points indicate the observed mean genetic distance between each pair of patients for the TIV-responding CDR3 sequences in the B cell data. Violin plots show the null distribution of mean pairwise distance values for each patient comparison (see “Methods” for how the null distribution was created). A point below the null distribution indicates convergent TIV-responding CDR3 sequences and above indicates divergent TIV-responding CDR3 sequences. Patient comparisons are sorted by observed mean pairwise genetic distance and distributions are colored by their empirical p value. P1 vs. P4 p value = 0.001