Table 1.
Top ten TIV-responding heavy chain V genes
| Gene name | Lit Ab Freq. | Combined | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 |
|---|---|---|---|---|---|---|---|
| IGHV3-23 | 0.10345 | 1.08E-14 | 1.54E-05 | 4.55E-05 | 0.00529688 | 0.00010769 | 0.00015385 |
| IGHV1-69 | 0.23707 | 5.04E-14 | 0.00043284 | 0.00290909 | 0.00028125 | 6.15E-05 | 1.54E-05 |
| IGHV3-30 | 0.03879 | 7.19E-13 | 0.00153731 | 0.00154546 | 0.00025 | 0.00069231 | 1.54E-05 |
| IGHV3-7 | 0.04310 | 1.15E-12 | 0.00020896 | 0.00792424 | 1.54E-05 | 0.00010769 | 0.00389231 |
| IGHV4-61 | 0.00215 | 1.16E-12 | 0.00132836 | 7.58E-05 | 0.02834375 | 3.08E-05 | 0.00012308 |
| IGHV4-31 | 0.00431 | 1.78E-12 | 0.00110448 | 0.00424242 | 0.0015625 | 3.08E-05 | 7.69E-05 |
| IGHV3-48 | 0.01940 | 2.36E-12 | 0.00032836 | 0.00040909 | 0.0001875 | 0.00096923 | 0.00096923 |
| IGHV4-59 | 0.15302 | 2.77E-12 | 0.00011940 | 0.00013636 | 0.01929688 | 4.62E-05 | 0.00195385 |
| IGHV3-11 | 0.00431 | 3.14E-12 | 0.00037313 | 0.00074242 | 0.00025 | 0.00015385 | 0.00306154 |
| IGHV3-30-3 | 0 | 4.71E-11 | 0.00219403 | 0.01130303 | 0.00153125 | 0.00115385 | 1.54E-05 |
Lists the top ten scoring IGHV genes in the FPCA-based test for the B cell data. “Lit. Ab Freq.” lists the frequency for each of the V genes in the literature-curated dataset. “Combined” lists the p values for each of the V genes after using Fisher’s method to combine the p values from the FPCA-based test across all the patients. Patient 1–5 lists the p values for each of the individual patients from the FPCA-based test. Genes are sorted by combined p value