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. 2016 Jun 3;16:350. doi: 10.1186/s12885-016-2371-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Methylation profiles of the eight promoter CGIs in OL tissues and identification of aberrant methylation in OLs with dysplasia. a The methylation statuses of the eight genes showing promoter methylation in OSCC tissues were examined in 24 OL tissues. Six and two of the eight genes were expressed and unexpressed, respectively, in normal oral mucosae. Thirteen and 11 cases were OLs with and without dysplasia, respectively. The OLs with dysplasia were categorized into mild (n = 5), moderate (n = 6), and severe grade (n = 2). Five of the six expressed genes and both of the unexpressed genes showed promoter methylation in OL(s) with dysplasia. b When the number of methylated genes was summed and compared between OLs with and without dysplasia, the methylation status showed a significant association with the presence of dysplasia (p < 0.0001)