Table 2.
Associations of differences between Δage (per 5 years) according to different predictors of DNAmage with all-cause and cause-specific mortality
| Causes of death (N of events; %) |
Predictor | Cox model 1a
(Hazard ratios) |
Cox model 2b
(Hazard ratios) |
|---|---|---|---|
| All-cause mortality | |||
| (602; 32.3) | DNAmage (Horvath) | 1.22 (1.10–1.36) | 1.23 (1.10–1.38) |
| (602; 32.3) | DNAmage (Hannum) | 1.16 (1.00–1.34)* | 1.10 (0.94–1.29) |
| Cancer mortality | |||
| (235; 12.6) | DNAmage (Horvath) | 1.20 (1.03–1.39) | 1.22 (1.03–1.45) |
| (235; 12.6) | DNAmage (Hannum) | 1.08 (0.87–1.35) | 1.03 (0.80–1.33) |
| Cardiovascular disease mortality | |||
| (194; 10.4) | DNAmage (Horvath) | 1.20 (1.02–1.42) | 1.19 (0.98–1.43) |
| (194; 10.4) | DNAmage (Hannum) | 1.13 (0.89–1.44) | 1.00 (0.79–1.29) |
*p = 0.0408
aModel 1: adjusted for chronological age (continuous), sex, batch effects, and leucocyte distribution
bModel 2: additionally adjusted for educational level, history of cancer diseases, history of CVD, hypertension, diabetes mellitus, smoking status (never/former vs. current), and body mass index (continuous)