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. 2016 Jun 3;18:128. doi: 10.1186/s13075-016-1025-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Oral administration of curcumin slowed progression of post-traumatic osteoarthritis in mice. Mice with destabilization of the medial meniscus (DMM) were treated daily with curcumin (Cur) or vehicle via oral gavage. Mice with DMM treated with curcumin exhibited improved Safranin O staining (a), lower Osteoarthritis Research Society International (OARSI) scores (b), and reduced synovitis (c) and subchondral plate thickness (d) at 8 weeks following surgery, compared to mice with DMM that were treated with vehicle (Veh). *P < 0.05, t test, n = 8/group. Representative histologic images are shown