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. 2016 Jun 3;18:128. doi: 10.1186/s13075-016-1025-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Topical application of curcumin nanoparticles reduced the degradation of articular cartilage matrix and reduced the expression of matrix metalloproteinase-13 (MMP-13) and a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS5). Intensity of immunohistochemical staining of type II collagen cleavage epitope (Col2-3/4 M) (a) and cleaved aggrecan (NITEGE) (b), and percentage of positive cells of immunohistochemical staining of MMP-13 (c), and of ADAMTS5 (d) in the articular cartilage of mice with destabilization of the medial meniscus (DMM) that were treated with curcumin nanoparticles (N-C) for 8 weeks following surgery were significantly reduced compared to mice with DMM treated with vehicle (Veh) (*p < 0.05, t test, n = 5/group). Scale bar = 100 μM. Representative immunohistochemical images are shown