Table 1.
Clinical data of the patients and histological characteristics of the uveal melanomas
| Variable | Total | Metastasis | No metastasis | P-Wert (Spearman’s Rho Test) | |
|---|---|---|---|---|---|
| p-value | r-value | ||||
| Number of patients | 49 | 28 | 21 | ||
| Sex | |||||
| Female | 21 (42.9 %) | 13 (26.5 %) | 8 (16.3 %) | 0.894 | −0.019 |
| Male | 28 (57.1 %) | 15 (30.6 %) | 13 (26.5 %) | ||
| LTD (mm) | |||||
| Median | 15a | 15.5b | 15b | 0.164 | 0.208 |
| Range | 5–30 | 10–30 | 5–28 | ||
| Height (mm) | |||||
| Median | 7c | 7.5a | 6b | 0.263 | 0.175 |
| Range | 2–22 | 2- | 2–12 | ||
| Ciliary body invasion | 22d (44.9 %) | 16 (57.1 %) | 6d (28.6 %) | 0.108 | 0.230 |
| Scleral invasion | 46d (93.9 %) | 26 (92.9 %) | 20d (95.2 %) | 0.247 | −0.149 |
| Extrascleral extension | 7e (14.3 %) | 5d (17.9 %) | 2d (9.5 %) | 0.058 | −0.282 |
| Invasion | |||||
| of Bruch’s membrane | 27d (55.1 %) | 16 (57.1 %) | 11d (52.4 %) | 0.732 | 0.050 |
| of the optic nerve head | 2d (4.1 %) | 1 (3.6 %) | 1d (4.7 %) | 0.560 | −0.088 |
| Histological subtype | |||||
| Epithelioid | 9 (18.4 %) | 8 (28.6 %) | 0 (0 %) | 0.005 | 0.387 |
| Mixed | 22 (44.9 %) | 12 (42.9 %) | 11 (52.4 %) | ||
| Spindle cell | 18 (36.7 %) | 8 (28.6 %) | 10 (47.6 %) | ||
| TNM | |||||
| Stage I | 5f (10.9 %) | 0d (0.0 %) | 5c (26.3 %) | 0.073 | 0.264 |
| Stage II | 10 (21.7 %) | 6 (22.2 %) | 4 (21.1 %) | ||
| Stage III | 16 (34.8 %) | 11 (40.7 %) | 5 (26.3 %) | ||
| Stage IV | 15 (32.6 %) | 10 (37.0 %) | 5 (26.3 %) | ||
| High CD105 expression | 26d (54.2 %) | 18d (66.7 %) | 8 (38.1 %) | 0.098 | 0.237 |
| High vWF expression | 26 (53.1 %) | 18 (64.3 %) | 8 (21.1 %) | 0.129 | 0.216 |
| VM | 25 (51.0 %) | 19 (67. %) | 6 (28.6 %) | 0.016 | 0.342 |
LTD largest tumor diameter, mm Millimeter, TNM Tumor Node Metastasis, CD105 Endoglin, vWF von Willebrand Factor, VM Vasculogenic Mimicry
a4 missing values, b2 missing values, c6 missing values, d1 missing value, e2 missing values, f3 missing values