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. 2016 Jun 3;35:87. doi: 10.1186/s13046-016-0366-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Subcellular distribution of HBwx and HBx and characteristics of HBwx distribution in HBV-associated HCC specimens detected by immunohistochemistry. a HBwx immunoreactivity was mainly observed in the nucleus and in the cytoplasm surrounding the nuclear membrane (e). Immunohistochemical staining of HBx revealed diffuse positivity in the hepatocytes, especially in cytoplasm (f) (a-d, original magnification, ×100) (e-f, original magnification, ×400). b More intense and widespread HBwx immunoreactivity was observed in the small tumor masses (a, d) or the peripheral parts of the large tumor masses near the portal area (b, e); No HBwx immunoreactivity was observed in tumor cells of poorly differentiated hepatocellular carcinoma (c, f) (a-c, original magnification, ×100) (d-f, original magnification, ×200)